Kun Gou is also grateful to the support from the Summer Faculty Fellowship Program of the College of Arts and Sciences and a University Research Council Grant from Texas A&M University-San Antonio. įunding: This publication is supported by the Professional Development Fund of Texas A&M University- San Antonio for Dr. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The URLs for all the data stored in a public repository are as below. Received: JanuAccepted: JPublished: August 11, 2021Ĭopyright: © 2021 Gou et al. Integration of further biochemical and cellular activities that initiate and mediate such complex growth remains to be explored.Ĭitation: Gou K, Baek S, Lutnesky MMF, Han H-C (2021) Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix. The results reveal that complex growth may occur inside tissues to achieve certain tubular deformations. Modeling such mixed growth represents an advancement beyond commonly used uniform growth inside tissues to study tubular deformations. The computational results demonstrate that both negative radial growth and positive circumferential growth facilitate thinning and dilation. An advanced hyperelasticity theory called morphoelasticity is employed to model the deformations, and a growth tensor is used to represent growth in three principle directions. In this article, the human cervix during pregnancy is studied as an example to show how cervical thinning and dilation are generated by growth. However, deformation-targeted growth is rarely studied. Configuring growth profiles that achieve particular deformation patterns is critical for analyzing potential pathological conditions and for developing corresponding clinical treatments for tubular organ dysfunctions. Growth is a significant factor that results in deformations of tubular organs, and particular deformations associated with growth enable tubular organs to perform certain physiological functions.

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